What is ROC?
The Resuscitation Outcomes Consortium (ROC) was created to conduct clinical research in the areas of cardiopulmonary resuscitation and traumatic injury. ROC consists of 10 Regional Clinical Centers (RCCs), one satellite site and a Data and Coordinating Center (DCC) that will provide the necessary infrastructure to conduct multiple collaborative trials to aid rapid translation of promising scientific and clinical advances to improve resuscitation outcomes. Trials may evaluate existing or new therapies (such as pharmacologic immune modulators) as well as clinical management strategies (such as new resuscitative fluids, novel hemorrhage control strategies, the use of cerebral protection and neurologic preservation, metabolically directed therapies, and alternative methods of delivering CPR or defibrillation).
Who are the Sponsors?
- National Heart, Lung and Blood Institute (the lead federal government sponsor of this program) and other institutes within the National Institute of Health
- Institute of Circulatory and Respiratory Health of the Canadian Institutes of Health Research
- US Army Medical Research & Materiel Command
- Defence Research and Development Canada
- Heart and Stroke Foundation of Canada
- American Heart Association
ROC has been renewed until 2015 with direct study commitment of the sponsors is for 6 year funding of approximately $10 million per year.
Who will conduct the research?
The ROC consists of EMS systems and hospitals in the cities or regions listed below.
Regional Clinical Centers
|Memphis Resuscitation Research Center||Tim Fabian, MD, Principal Investigator|
|San Francisco Clinical Center||Mitchell Cohen, MD, Principal Investigator|
|Cincinnati Clinical Center||Peter Muskat, MD, Principal Investigator|
|Houston Clinical Center||Bryan Cotton, MD, Principal Investigator|
|Houston Clinical Coordinating Center||Barbara Tilley, PhD, Principal Investigator|
|Houston Data Coordinating Center||John Holcomb, MD, Principal Investigator|
|Toronto,Sunnybrook Clinical Center||Sandro Rizoli, MD, Principal Investigator|
|Baltimore Clinical Center||Thomas Scalea, MD, Principal Investigator|
|Tucson Clinical Center||Terence O'Keeffe, MD, Principal Investigator|
|Los Angeles Clinical Center||Kenji Inaba, Principal Investigator|
|St. Paul Regions||Ralph Frascone, MD, Principal Investigator|
|Mayo Clinic Rochester||Martin Zielinski, MD, Principal Investigator|
|Minneapolis/Hennepin County||Paul Nystrum, MD, Principal Investigator|
The Study Chair is Myron L. Weisfeldt, MD, Chair of Medicine at Johns Hopkins; the co-chair for cardiac arrest is Joseph Ornato, MD, Head of the Emergency Medicine Department at the Medical College of Virginia; and the co-chair for trauma is David Hoyt, MD, Executive Director, American College of Surgeons, Chicago, IL. The Clinical and Data Coordinating Center is located at the University of Washington, Seattle, WA under the direction of Susanne May, PhD, Gerald van Belle, PhD and Graham Nichol, MD. The Ethics Officer is Jeremy Sugarman, MD, MPH, MA, Berman Bioethics Institute, Johns Hopkins University.
What kind of research will potentially be conducted?
Relevant clinical trials conducted by ROC may include, but are not limited to, the following scientific needs and considerations:
- Evaluation of pharmacologic interventions to address a three-phase (electrical, circulatory, and metabolic) approach to resuscitation from cardiac arrest.
- Evaluation of optimal strategies of fluid resuscitation including permissive hypotension, timing of initiation of infusion, and use of alternative fluids particularly after traumatic injury.
- Use of immune modulators in improving clinical outcomes by altering systemic and/or regional inflammatory responses accompanying shock or shock-like states.
- Evaluation of novel hemorrhage control strategies.
- Use of cerebral protection and neurologic preservation, with an emphasis on functional outcome.
- Evaluation of metabolically directed therapies, such as a rapid induction of moderate systemic hypothermia and other novel methods to reduce metabolic demands in the immediate post-arrest/resuscitation interval.
- Evaluation of alternative CPR approaches including device-assisted CPR including defibrillators.
- Evaluation of optimal ventilation and oxygen delivery systems and methods for airway protection.